Unlock Your Best Self

A licensed clinician reviews your health history to confirm eligibility. If they need more detail, they’ll follow up through secure messaging or a quick visit—then your plan is finalized and your program begins.

Not always. Some states allow an async flow (secure messaging + review). Others require a live visit. Either way, it’s designed to be simple and easy to complete.

Refills typically come with periodic check-ins (short forms and/or clinician follow-ups) to make sure the plan still matches your needs. Your clinician may adjust dosing over time.

Regulations and clinician requirements can differ by state, which can affect what’s available and whether a live visit is required.

Yes. If you want to transition to standalone longevity treatments, contact XMD to have the additives removed from your GLP-1 medication. Once that change is made, you may then qualify for standalone subscriptions for those longevity peptide products.

Yes, with clear medical guidelines.
If a patient is taking NR supplementation, such as NAD Dreams from Xyngular, they may also receive NAD+ as part of a GLP-1/GIP compounded prescription when clinically appropriate and determined by a licensed healthcare provider.
The amount of NAD+ included within a GLP-1/GIP medical protocol is intentionally limited and designed to support metabolic and cellular processes without unnecessary overlap.

However, patients are not prescribed a standalone NAD+ medication in addition to:

• NR supplementation (NAD Dreams), and/or
• NAD+ already included in their GLP-1/GIP compounded prescription

Why this matters

NR (nicotinamide riboside) is a well-studied NAD+ precursor that the body converts into NAD+. NR supplementation is commonly used to support:

• Mitochondrial energy production
• Cellular repair/renewal and resilience
• Metabolic function
• Healthy aging-related pathways

Because NR supplementation and NAD+ included within GLP-1/GIP protocols both contribute to NAD-related pathways, adding a standalone NAD+ prescription on top of NR supplementation and/or a GLP-1/GIP compound that already includes NAD+ is generally unnecessary and not medically appropriate.

Bottom line

NR supplementation (NAD Dreams) may be used alongside NAD+ included in a GLP-1/GIP compounded prescription when directed by a licensed healthcare provider. Standalone NAD+ prescriptions are not combined with NR supplementation and/or GLP-1/GIP compounds that already include NAD+.

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme derived from vitamin B3 that is present in every living cell. It plays a central role in:

• Cellular energy production and mitochondrial function
• DNA repair and cellular maintenance
• Cellular regeneration and resilience
• Neurotransmitter activity and normal brain function

NAD+ levels naturally decline with age. This decline has been associated with changes in energy levels, recovery capacity, cognitive performance, and metabolic efficiency. NAD+ therapy is used clinically to support these underlying cellular processes under the supervision of a licensed healthcare provider.

NAD+ plays a central role in cellular energy production and metabolic function. NAD+ therapy may be used to support:

• Cellular energy production and mitochondrial function
• Cognitive performance, focus, and mental clarity
• Reduced feelings of fatigue
• Support for healthy aging and longevity-related pathways
• DNA repair mechanisms and cellular resilience
• Muscle function and neurological health

Many individuals report improvements in overall vitality and quality of life when NAD+ therapy is used as part of a provider-directed wellness plan.

Some individuals may experience:

• Mild nausea
• Headache
• Flushing
• Temporary fatigue or discomfort during or after administration

Side effects, if they occur, are generally short-lived and may vary based on individual response and dosing. A licensed practitioner will help determine the most appropriate format and dose for your individual needs.

Depending on your state and clinician decision, NAD+ may be offered in more than one route (for example, injection or nasal). Your clinician guides what’s appropriate. NAD⁺ nasal spray offers a convenient, non-invasive option that can be used at home and avoids needles, making it appealing for maintenance or general wellness; however, absorption can vary between individuals, dosing is limited, and there is less clinical research supporting its effectiveness compared to injectable forms. In contrast, NAD⁺ injections (including IV, intramuscular, or subcutaneous) provide higher and more predictable bioavailability with precise dosing and faster systemic effects, which may be better suited for higher-dose or therapeutic protocols, though they are more invasive, typically more expensive, and require medical oversight.

NAD+ is compatible with several longevity treatments, but should not be combined with Methylene Blue. Your clinician makes the final call based on your health profile.

✓ Compatible  ·  ✗ Not recommended to combine  ·  — Same product. Final combinations are always clinician-determined.

Sermorelin is a synthetic peptide that mimics a naturally occurring growth hormone–releasing hormone and stimulates the pituitary gland to release endogenous growth hormone. Growth hormone plays an important role in growth, tissue repair, metabolism, and recovery. Unlike direct growth hormone replacement, sermorelin works by supporting the body’s own natural production of growth hormone.

Many patients experience benefits such as:

• Improved sleep quality
• Increased energy and overall vitality
• Enhanced mood and mental clarity
• Support for muscle recovery and maintenance of lean mass
• Support for bone health
• Metabolic support and favorable body composition changes

Individual results may vary based on overall health, dosing, and consistency of use. Sermorelin is typically used as part of a medically supervised wellness or metabolic support program.

Sermorelin is not prescribed as a primary weight loss medication. However, it may support weight management by stimulating endogenous growth hormone and insulin-like growth factor 1 (IGF 1), which are involved in:

• Metabolic efficiency and substrate utilization
• Fat metabolism
• Preservation of lean muscle mass during caloric restriction

Sermorelin is best viewed as a metabolic, body composition, and recovery support therapy that may complement a medically supervised weight management program, rather than a standalone weight loss treatment.

Common side effects are generally mild and may include:

• Injection site irritation, redness, or swelling
• Headache
• Flushing
• Dizziness or nausea
• Temporary sleepiness or restlessness

These effects are typically short-lived and may vary by individual. If symptoms worsen or persist, pause use and consult your medical provider. Seek immediate medical attention if you experience signs of a severe allergic reaction, including facial swelling or difficulty breathing.

Sermorelin is the most broadly compatible of the longevity treatments and can be combined with any of the others. Your clinician makes the final determination.

✓ Compatible  ·  ✗ Not recommended to combine  ·  — Same product. Final combinations are always clinician-determined.

B12 MIC is an injectable formulation that combines:

• Vitamin B12
• Methionine
• Inositol
• Choline

These compounds work synergistically to support metabolism, liver health, and cellular energy production.

B12 MIC is commonly used in clinical and wellness settings to:

• Support fat and lipid metabolism
• Promote energy production and metabolic function
• Support liver-related metabolic and detoxification processes

It’s frequently incorporated into medically supervised weight management and metabolic optimization programs, particularly to support energy levels and metabolic function during periods of caloric restriction.

Side effects are generally mild and may include:

• Redness, tenderness, or irritation at the injection site
• Mild digestive discomfort
• Increased urination

In rare cases, allergic reactions may occur. If you experience unusual, persistent, or worsening symptoms, discontinue use and consult your healthcare provider.

B12 MIC may not be appropriate for individuals with certain medical conditions, including:

• Liver or kidney conditions
• Known allergies or sensitivities to vitamin B12 (cobalamin), methionine, inositol, or choline
• Conditions affecting nutrient metabolism

Individuals who are pregnant or breastfeeding should consult a qualified healthcare provider before use. Always discuss your medical history with a licensed practitioner to determine whether B12 MIC is appropriate for you.

We offer an option with methylated B12, so you can choose the form that best supports your needs. Availability of the methylated B12 option may vary depending on your state regulations and the pharmacy dispensing the product near you.

B12-MIC is compatible with several longevity treatments, but should not be combined with Methylene Blue. Your clinician makes the final determination.

✓ Compatible  ·  ✗ Not recommended to combine  ·  — Same product. Final combinations are always clinician-determined.

Designed for adults 18 and older, with no defined upper age limit. Always consult a qualified healthcare professional to determine what's right for you.

Some may feel a lighter, more energized state within 24–72 hours. More commonly, noticeable changes in energy, recovery, or skin tone appear after several weeks of consistent use. The timeline depends on your baseline glutathione levels and oxidative burden. The more toxin load or liver support you need, benefits may take longer to notice. Results may vary.

Glutathione is generally well-tolerated when used as directed. Some individuals may experience mild, temporary side effects, including:

• Redness, swelling, or irritation at the injection site
• Headache or dizziness
• Mild nausea (rare)
• A temporary feeling of warmth or flushing, especially if administered too quickly
• A mild sulfur-like taste in the mouth
• Rarely, an allergic reaction

If you have asthma, use caution. Rapid administration (more common with IV use) may trigger temporary bronchospasm or worsen symptoms, particularly if your asthma is not well controlled or you are experiencing a flare.

If you are experiencing any increase in symptoms reach out to the XMD Wellness Care team: 218-235-8390, support@xmdwellness.com

Glutathione is compatible with most longevity treatments, but should not be combined with Methylene Blue. Your clinician makes the final determination.

✓ Compatible  ·  ✗ Not recommended to combine  ·  — Same product. Final combinations are always clinician-determined.

Designed for adults 18 and older, with no defined upper age limit. Always consult a qualified healthcare professional to determine what's right for you.

You may begin to notice initial changes within the first one to two weeks. However, individual experiences can vary, and more meaningful or sustained benefits typically develop with consistent use over time. As your body continues to respond and adapt, results often build progressively, leading to a more noticeable and lasting impact. Results may vary.

The majority of individuals do not encounter any adverse effects from using Methylene Blue, outside of a blue tinge to urine or stool, which is normal and expected.

Should you experience any sensitivity or side effects after using Methylene Blue, consider decreasing the frequency of use. As with any side effect, if symptoms continue, cease use and get in touch with our team. Some side effects that can be experienced with Methylene Blue include headache, GI upset including nausea or diarrhea, or dizziness.

If you are experiencing any increase in symptoms reach out to the XMD Wellness Care team: 218-235-8390, support@xmdwellness.com

Methylene Blue has the most restrictions of the longevity treatments — it should only be combined with Sermorelin. It is not compatible with NAD+, B12-MIC, or Glutathione. Your clinician makes the final determination.

✓ Compatible  ·  ✗ Not recommended to combine  ·  — Same product. Final combinations are always clinician-determined.